Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses
Identifieur interne : 000831 ( Main/Exploration ); précédent : 000830; suivant : 000832Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses
Auteurs : Simon Meyer ; Catherine Giannopoulou ; Delphine Courvoisier ; Martin Schimmel ; Frauke Müller ; Andrea MombelliSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2016.
Abstract
To compare in persons aged 70 years or older the clinical and inflammatory changes occurring around implants and natural teeth during and after a phase of undisturbed plaque accumulation.
Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored for 3 weeks. Twelve biomarkers were assessed in gingival and peri‐implant crevicular fluid (
During 3 weeks of oral hygiene abstention, the gingival index (
The different biomarkers reacted variably.
In an elderly cohort, plaque accumulation induced an inflammatory reaction around both teeth and implants. Although there was less plaque accumulation on implants, the peri‐implant mucosa showed a stronger clinical response than gingiva.
Url:
DOI: 10.1111/clr.12912
PubMed: 27333829
PubMed Central: 5599942
Affiliations:
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Clinical and biological responses</title><author><name sortKey="Meyer, Simon" sort="Meyer, Simon" uniqKey="Meyer S" first="Simon" last="Meyer">Simon Meyer</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Giannopoulou, Catherine" sort="Giannopoulou, Catherine" uniqKey="Giannopoulou C" first="Catherine" last="Giannopoulou">Catherine Giannopoulou</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Courvoisier, Delphine" sort="Courvoisier, Delphine" uniqKey="Courvoisier D" first="Delphine" last="Courvoisier">Delphine Courvoisier</name><affiliation><nlm:aff id="clr12912-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Schimmel, Martin" sort="Schimmel, Martin" uniqKey="Schimmel M" first="Martin" last="Schimmel">Martin Schimmel</name><affiliation><nlm:aff id="clr12912-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Muller, Frauke" sort="Muller, Frauke" uniqKey="Muller F" first="Frauke" last="Müller">Frauke Müller</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Mombelli, Andrea" sort="Mombelli, Andrea" uniqKey="Mombelli A" first="Andrea" last="Mombelli">Andrea Mombelli</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27333829</idno><idno type="pmc">5599942</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599942</idno><idno type="RBID">PMC:5599942</idno><idno type="doi">10.1111/clr.12912</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002B19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B19</idno><idno type="wicri:Area/Pmc/Curation">002B19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B19</idno><idno type="wicri:Area/Pmc/Checkpoint">000700</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000700</idno><idno type="wicri:Area/Ncbi/Merge">006816</idno><idno type="wicri:Area/Ncbi/Curation">006816</idno><idno type="wicri:Area/Ncbi/Checkpoint">006816</idno><idno type="wicri:doubleKey">0905-7161:2016:Meyer S:experimental:mucositis:and</idno><idno type="wicri:Area/Main/Merge">000831</idno><idno type="wicri:Area/Main/Curation">000831</idno><idno type="wicri:Area/Main/Exploration">000831</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses</title><author><name sortKey="Meyer, Simon" sort="Meyer, Simon" uniqKey="Meyer S" first="Simon" last="Meyer">Simon Meyer</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Giannopoulou, Catherine" sort="Giannopoulou, Catherine" uniqKey="Giannopoulou C" first="Catherine" last="Giannopoulou">Catherine Giannopoulou</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Courvoisier, Delphine" sort="Courvoisier, Delphine" uniqKey="Courvoisier D" first="Delphine" last="Courvoisier">Delphine Courvoisier</name><affiliation><nlm:aff id="clr12912-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Schimmel, Martin" sort="Schimmel, Martin" uniqKey="Schimmel M" first="Martin" last="Schimmel">Martin Schimmel</name><affiliation><nlm:aff id="clr12912-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Muller, Frauke" sort="Muller, Frauke" uniqKey="Muller F" first="Frauke" last="Müller">Frauke Müller</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Mombelli, Andrea" sort="Mombelli, Andrea" uniqKey="Mombelli A" first="Andrea" last="Mombelli">Andrea Mombelli</name><affiliation><nlm:aff id="clr12912-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Oral Implants Research</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="clr12912-sec-0001"><title>Objectives</title><p>To compare in persons aged 70 years or older the clinical and inflammatory changes occurring around implants and natural teeth during and after a phase of undisturbed plaque accumulation.</p></sec><sec id="clr12912-sec-0002"><title>Material and methods</title><p>Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored for 3 weeks. Twelve biomarkers were assessed in gingival and peri‐implant crevicular fluid (<styled-content style="fixed-case">GCF</styled-content>,<styled-content style="fixed-case"> PCF</styled-content>).</p></sec><sec id="clr12912-sec-0003"><title>Results</title><p>During 3 weeks of oral hygiene abstention, the gingival index (<styled-content style="fixed-case">GI</styled-content>) continuously increased. On day 21, there were significantly more sites with <styled-content style="fixed-case">GI</styled-content> >1 at implants than at teeth. After restarting oral hygiene, the <styled-content style="fixed-case">GI</styled-content> decreased markedly in both groups. Throughout the experiment, the plaque index was significantly higher on teeth than on implants.</p><p>The different biomarkers reacted variably. <styled-content style="fixed-case">IL</styled-content>‐1β increased significantly with plaque accumulation. <styled-content style="fixed-case">IL</styled-content>‐1β, <styled-content style="fixed-case">GM</styled-content>‐<styled-content style="fixed-case">CSF</styled-content>,<styled-content style="fixed-case"> TNF</styled-content>‐α, and <styled-content style="fixed-case">IFN</styled-content>‐γ were significantly higher in <styled-content style="fixed-case">GCF</styled-content> compared to <styled-content style="fixed-case">PCF</styled-content> at day 21. <styled-content style="fixed-case">IL</styled-content>‐8 decreased significantly in <styled-content style="fixed-case">GCF</styled-content> up to day 14. <styled-content style="fixed-case">MIP</styled-content>‐1β decreased significantly in <styled-content style="fixed-case">GCF</styled-content>, but not in <styled-content style="fixed-case">PCF</styled-content>. At the 3‐week follow‐up, the levels of all biomarkers assessed in <styled-content style="fixed-case">GCF</styled-content> and <styled-content style="fixed-case">PCF</styled-content> had returned to baseline values.</p></sec><sec id="clr12912-sec-0004"><title>Conclusions</title><p>In an elderly cohort, plaque accumulation induced an inflammatory reaction around both teeth and implants. Although there was less plaque accumulation on implants, the peri‐implant mucosa showed a stronger clinical response than gingiva.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Courvoisier, Delphine" sort="Courvoisier, Delphine" uniqKey="Courvoisier D" first="Delphine" last="Courvoisier">Delphine Courvoisier</name><name sortKey="Giannopoulou, Catherine" sort="Giannopoulou, Catherine" uniqKey="Giannopoulou C" first="Catherine" last="Giannopoulou">Catherine Giannopoulou</name><name sortKey="Meyer, Simon" sort="Meyer, Simon" uniqKey="Meyer S" first="Simon" last="Meyer">Simon Meyer</name><name sortKey="Mombelli, Andrea" sort="Mombelli, Andrea" uniqKey="Mombelli A" first="Andrea" last="Mombelli">Andrea Mombelli</name><name sortKey="Muller, Frauke" sort="Muller, Frauke" uniqKey="Muller F" first="Frauke" last="Müller">Frauke Müller</name><name sortKey="Schimmel, Martin" sort="Schimmel, Martin" uniqKey="Schimmel M" first="Martin" last="Schimmel">Martin Schimmel</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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